Q96PH1

NOX5 (NADPH oxidase 5) is a member of the NADPH oxidase family. NOX5 plays a crucial role in generating reactive oxygen species, particularly superoxide, which is essential for various cellular processes, including signaling pathways that regulate cell proliferation and apoptosis. Notably, NOX5 is unique among its family due to its N-terminal region, which contains three EF-hand motifs that bind calcium ions, allowing NOX5 to respond to intracellular calcium fluctuations. This calcium sensitivity is vital for Nox5 function, as calcium binding enables direct activation in response to physiological stimuli, thereby influencing processes such as immune response and vascular function. NOX5 expression in lymphoid organs and testis highlights its importance in both immune system regulation and reproductive biology, making NOX5 a significant target for research in these areas.