P45452

MMP-13 is a member of the peptidase M10 family of matrix metalloproteinases (MMPs). MMP-13 is a crucial enzyme located in the extracellular matrix, where MMP-13 plays a vital role in the degradation of collagen types I, II, and III, facilitating essential processes such as fetal bone development and adult bone remodeling. Beyond physiological functions, MMP-13 is significantly involved in pathological conditions like cancer metastasis and osteoarthritis, where MMP-13 contributes to the breakdown of extracellular matrix components, promoting tumor invasion and joint degradation. Understanding the expression and regulation of MMP-13 is essential for developing targeted therapies aimed at mitigating these diseases.