LIPC also known as Hepatic Lipase is a liver- and endothelium-associated lipolytic enzyme that hydrolyzes triglycerides and phospholipids in circulating lipoproteins, thereby remodeling HDL and apoB-containing particles. Through its actions at the hepatocyte surface and within the vascular compartment, hepatic lipase contributes to lipoprotein uptake, reverse cholesterol transport, and broader lipid homeostasis. Variation in LIPC expression or activity has been linked to altered plasma lipid profiles, including changes in HDL cholesterol and triglyceride-rich lipoproteins, connecting this pathway to cardiometabolic phenotypes. As a nodal regulator of lipoprotein metabolism, LIPC is frequently studied in hepatocyte biology, lipid trafficking, and nutrient-responsive transcriptional networks.