KCNQ1 also known as KVLQT1 is a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. KCNQ1 protein plays a crucial role in cardiac and auditory function as part of voltage-gated potassium channels essential for action potential repolarization in excitable cells. KCNQ1, in conjunction with β subunit KCNE1, is predominantly expressed in heart and cochlea, where KCNQ1 regulates slow, depolarization-activated potassium current. This regulation maintains electrical stability of cardiac cells and ensures proper hearing function. Mutations in KCNQ1 gene can lead to serious cardiac conditions, such as Long QT syndrome, by disrupting normal electrical signaling, while alterations in KCNQ4 are associated with hearing loss.