Polyclonal Antibodies - Phospho-LEF1 (Ser42) Rabbit Polyclonal Antibody

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Phospho-LEF1 (Ser42) Rabbit Polyclonal Antibody

Catalog #：EAB14233

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB14233-30UL	In Stock	30ul	$163.50
EAB14233-100UL	In Stock	100ul	$343.50
EAB14233-200UL	In Stock	200ul	$553.50

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	EbioCell	Phone：(540) 808-3925
	Imperial Business Park 4819 Emperor Boulevard,	E-mail：order@ebiocell.com
United States	Suite 408 Durham, NC 27703, USA	Web：www.ebiocell.com

Product Information
Applications	WB, IHC-P
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:50-300
MW (kDa)	44
Conjugate	Unconjugate
Specificity	Phospho-LEF1 (Ser42) Rabbit Polyclonal Antibody detects endogenous levels of LEF1 protein only when phosphorylated at Ser42.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Lymphoid enhancer binding factor 1; ECTD1; LEF-1; TCF10; ECTD17; TCF7L3; TCF1ALPHA; LEF1
Gene Aliases	LEF1
UniProt ID	Q9UJU2
Entrez Gene ID	51176

Product Description

LEF1 also known as Lymphoid enhancer binding factor 1 is a member of the TCF/LEF family of transcription factors, plays a crucial role in the Wnt signaling pathway, which is essential for various developmental processes and cellular functions. LEF1 is primarily located in the nucleus, where LEF1 interacts with β-catenin to regulate the transcription of Wnt target genes. Nuclear localization of LEF1 allows for precise control of gene expression in response to Wnt signaling, influencing cell fate decisions during embryonic development and tissue homeostasis. Dysregulation of LEF1 and associated pathways can lead to various diseases, including cancer, highlighting the importance of studying LEF1 for understanding tumorigenesis and potential therapeutic interventions.

Product Image Gallery
Western blot analysis of extracts on 293 cells treated with Paclitaxel, using Phospho-LEF1 (Ser42) Rabbit Polyclonal Antibody (EAB14233) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide. Immunohistochemical analysis of paraffin-embedded Human gastric adenocarcinoma tissue, using Phospho-LEF1 (Ser42) Rabbit Polyclonal Antibody (EAB14233) at 1:200 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol