Q9UJU2

LEF1 also known as Lymphoid enhancer binding factor 1 is a member of the TCF/LEF family of transcription factors, plays a crucial role in the Wnt signaling pathway, which is essential for various developmental processes and cellular functions. LEF1 is primarily located in the nucleus, where LEF1 interacts with β-catenin to regulate the transcription of Wnt target genes. Nuclear localization of LEF1 allows for precise control of gene expression in response to Wnt signaling, influencing cell fate decisions during embryonic development and tissue homeostasis. Dysregulation of LEF1 and associated pathways can lead to various diseases, including cancer, highlighting the importance of studying LEF1 for understanding tumorigenesis and potential therapeutic interventions.