Polyclonal Antibodies - IRF-8 Rabbit Polyclonal Antibody

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IRF-8 Rabbit Polyclonal Antibody

Catalog #：EAB14210

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB14210-30UL	In Stock	30ul	￡97.90
EAB14210-100UL	In Stock	100ul	￡218.90
EAB14210-200UL	In Stock	200ul	￡372.90

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email us at info@ebiocell.com

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, ELISA
Species Reactivity	Human, Mouse
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000
MW (kDa)	48
Conjugate	Unconjugate
Specificity	IRF-8 Rabbit Polyclonal Antibody detects endogenous levels of IRF-8 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Interferon regulatory factor 8; Interferon consensus sequence-binding protein; ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP; IRF8
Gene Aliases	IRF8
UniProt ID	Q02556
Entrez Gene ID	3394

Product Description

IRF-8 also known as ICSBP is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. IRF-8 plays a crucial role as a transcription factor in the regulation of immune responses, particularly in the signaling pathways mediated by interferon-gamma (IFN-γ) during the differentiation of dendritic cells and macrophages. IRF-8 physically interacts with TRAF6, a key adaptor protein that modulates Toll-like receptor (TLR) signaling, facilitating the cross-talk between IFN-γ and TLR pathways, which is essential for effective immune responses. IRF-8 has been shown to antagonize the oncogenic Bcr/Abl fusion protein by downregulating Bcl-2, highlighting a potential role in cancer biology.

Product Image Gallery
Western blot analysis of extracts on THP-1 cells, using IRF-8 Rabbit Polyclonal Antibody (EAB14210) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol