IGFBP5 also known as IBP5 plays a crucial role in regulating the bioavailability of insulin-like growth factors (IGFs), which are essential for various cellular processes, including growth, differentiation, and survival. IGFBP5 is primarily secreted by myoblasts and is believed to be instrumental in muscle differentiation, highlighting its importance in muscle development and repair. Additionally, IGFBP5 can modulate the actions of IGFs independently, suggesting distinct biological functions beyond its role as a binding protein. IGFBP5′s ability to interact with other proteins and influence signaling pathways makes IGFBP5 a significant player in the complex network of growth factor regulation.