SKU-Pack Size | Availability | Size | Price | |
EAB14168-30UL | In Stock | 30ul | $133.50 | |
EAB14168-100UL | In Stock | 100ul | $298.50 | |
EAB14168-200UL | In Stock | 200ul | $508.50 |
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EbioCell | Phone:(540) 808-3925 |
Imperial Business Park 4819 Emperor Boulevard, | E-mail:order@ebiocell.com | |
United States | Suite 408 Durham, NC 27703, USA | Web:www.ebiocell.com |
Product Information | |
Applications | WB, IHC-P, IF, ELISA |
Species Reactivity | Human, Mouse |
Host / Isotype | Rabbit IgG |
Clonality | Polyclonal |
Applications Dilutions | WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
MW (kDa) | 117 |
Conjugate | Unconjugate |
Specificity | IFIH1/MDA-5 Rabbit Polyclonal Antibody detects endogenous levels of IFIH1/MDA-5 protein. |
Purification | Affinity purification |
Concentration | 1mg/ml |
Format | Liquid |
Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
Shipping | Gel Pack |
Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
Research Use | For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. |
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
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Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
Product Bioinformatics | |
Synonym(s) | IFIH1; MDA5; RH116; Interferon-induced helicase C domain-containing protein 1; Melanoma differentiation-associated gene 5 |
Gene Aliases | IFIH1 |
UniProt ID | |
Entrez Gene ID |
Product Description | |
IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons. It has been shown that Coronaviruses (CoVs) as well as various other virus families, are capable of evading the MDA5-dependent interferon response, thus impeding the activation of the innate immune response to infection. MDA5 has also been shown to play an important role in enhancing natural killer cell function in malaria infection. In addition to its protective role in antiviral responses, MDA5 has been implicated in autoimmune and autoinflammatory diseases such as type 1 diabetes, systemic lupus erythematosus, and Aicardi-Goutieres syndrome |
Product Image Gallery | |
![]() Western blot analysis of extracts on different cells, using IFIH1/MDA-5 Rabbit Polyclonal Antibody (EAB14168) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Lane1: Jurkat Lane2: Mouse brain |
Specific Protocols | |