Polyclonal Antibodies - HAND2 Rabbit Polyclonal Antibody

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HAND2 Rabbit Polyclonal Antibody

Catalog #：EAB14142

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB14142-30UL	In Stock	30ul	￡97.90
EAB14142-100UL	In Stock	100ul	￡218.90
EAB14142-200UL	In Stock	200ul	￡372.90

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, ELISA
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000
MW (kDa)	23
Conjugate	Unconjugate
Specificity	HAND2 Rabbit Polyclonal Antibody detects endogenous levels of HAND2 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Heart and neural crest derivatives expressed 2; Hed; dHand; DHAND2; Thing2; bHLHa26; HAND2
Gene Aliases	HAND2
UniProt ID	P61296
Entrez Gene ID	9464

Product Description

HAND2 also known as dHAND is a member of the basic helix-loop-helix family of transcription factors. HAND2 plays a significant role in cardiac development, particularly in establishing left-right asymmetry in the heart. HAND2 is predominantly expressed on the right side of the looped heart tube and in the pulmonary ventricle, where HAND2 activates the transcription of essential genes such as Ufd1, which is involved in the ubiquitin-proteasome pathway, and Cdc45, a key player in DNA replication. Proper functioning of HAND2 is vital for the development of the heart′s structure, ensuring correct formation of heart chambers during cardiogenesis. HAND2 is expressed in sympathetic neurons and chromaffin cells throughout embryonic and fetal development, highlighting HAND2′s importance in neural crest development.

Product Image Gallery
Western blot analysis of extracts on K562 cells, using HAND2 Rabbit Polyclonal Antibody (EAB14142) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol