TNFR2 also known as TNF-R2, TNFRSF1B is a member of the TNF-receptor superfamily. TNFR2 plays a crucial role in mediating the effects of tumor necrosis factor (TNF), a key cytokine involved in inflammation and immune responses. This receptor is primarily expressed on immune cells and is essential for regulating cell survival, proliferation, and differentiation. TNFR2 signaling is associated with anti-apoptotic pathways, which can influence the outcome of various immune responses and contribute to the pathogenesis of autoimmune diseases and cancer. The interaction of TNFR2 with TNF can lead to the recruitment of various signaling molecules, including TRAF2 and TRAF1, which are pivotal for downstream signaling cascades that promote cell survival and inflammatory responses.