P01033

TIMP1 plays a crucial role in regulating extracellular matrix remodeling by inhibiting metalloproteinases, which are enzymes responsible for degrading various components of the extracellular matrix. This function is particularly important in processes such as wound healing, tissue repair, and cancer progression, where maintaining balance between matrix degradation and synthesis is vital for tissue integrity. TIMP-1 interacts with other tissue inhibitors of metalloproteinases, including TIMP2, TIMP3, and TIMP4, which further underscores TIMP1′s significance in modulating metalloproteinase activity and influencing cellular behaviors. TIMP1 expression is regulated by various factors, including parathyroid hormone, highlighting TIMP1′s involvement in complex signaling pathways that govern cellular responses in different physiological and pathological contexts.