TET2 (Tet oncogene family member 2) also known as KIAA1546 is a 2,002 amino acid protein that is expressed in a variety of tissues, including brain, kidney, heart, lung, muscle and stomach, and exists as three alternatively spliced isoforms. TET2 is a critical enzyme involved in DNA demethylation, playing a vital role in epigenetic regulation and maintenance of normal hematopoiesis. Proper functioning of TET2 is essential for preventing aberrant cell growth, and mutations are frequently associated with myeloid malignancies and other cancers, highlighting importance in both normal physiology and disease.