P08047

SP1(Specificity protein 1) is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. SP1 plays a crucial role in gene expression, cell growth, differentiation, and apoptosis. Initially identified as a factor that activates transcription from the SV40 promoter by binding to multiple GC boxes in the 21-base pair repeats, SP1′s DNA-binding specificity is conferred by three Cys2His2-type zinc finger motifs. Phosphorylation of SP1 can modulate activity and DNA-binding affinity, affecting the transcription of target genes. Located predominantly in the nucleus, SP1′s localization is essential for function as a transcriptional regulator. Dysregulation of SP1 has been implicated in various diseases, including cancer, highlighting importance in maintaining normal cellular functions.