O14543

SOCS3 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SOCS3 plays a crucial role in the negative regulation of cytokine signaling, which is vital for maintaining immune homeostasis and preventing excessive inflammatory responses. SOCS3 is primarily located in the cytoplasm, where SOCS3 interacts with various signaling pathways, including those activated by interleukin-6 (IL-6). SOCS3′s ability to inhibit these pathways is essential for controlling the duration and intensity of cytokine signaling, thereby preventing chronic inflammation and autoimmune diseases. Additionally, SOCS3 undergoes post-translational modifications, such as phosphorylation, which can influence SOCS3′s stability and activity, further underscoring SOCS3′s importance in cellular signaling networks.