P16581

E-Selectin also known as ELAM1, CD62E, SELE is a crucial adhesion molecule expressed on the surface of endothelial cells in response to pro-inflammatory cytokines. E-Selectin plays a crucial role in the immune response by mediating the adhesion of leukocytes to the endothelium during inflammation. E-Selectin is primarily expressed on the surface of endothelial cells that have been stimulated by cytokines, which is vital for the recruitment of immune cells to sites of injury or infection. E-Selectin′s ability to interact with specific carbohydrates on leukocytes facilitates the rolling and adhesion processes necessary for leukocyte extravasation, making E-Selectin an essential component in the inflammatory response. Furthermore, E-Selectin′s expression is tightly regulated and can be influenced by various cytokines, highlighting E-Selectin′s importance in both normal immune function and pathological conditions such as chronic inflammation and autoimmune diseases.