O00519

FAAH(fatty acid amide hydrolase) is a crucial membrane-bound enzyme that plays a significant role in the hydrolysis of various primary and secondary fatty acid amides, including important neuromodulatory compounds such as anandamide and oleamide. The enzymatic degradation of anandamide to arachidonic acid and oleamide to oleic acid is vital for terminating the signaling functions of these bioactive lipids, thereby regulating physiological processes such as pain sensation, mood, and appetite. FAAH exhibits equivalent catalytic efficiency for both amides and esters, allowing FAAH to function effectively as both an amidase and an esterase. This dual functionality is essential for maintaining the balance of lipid signaling in the body. FAAH is involved in the uptake of anandamide by establishing and sustaining an inward concentration gradient, which is critical for its physiological effects.