P00748

Factor XII also known as Hageman factor, F12 plays a crucial role in initiating the intrinsic pathway of blood coagulation, vital for hemostasis following vascular injury. Upon activation, Factor XII undergoes a conformational change that allows interaction with negatively charged surfaces, leading to Factor XI activation and subsequently triggering a cascade of proteolytic events that culminate in fibrin clot formation. This process is essential for preventing excessive bleeding and ensuring proper wound healing. Additionally, Factor XII has been implicated in various pathological conditions, including thrombosis and inflammation, making Factor XII a significant target for therapeutic interventions.