Q8TEK3

DOT1L also known as DOT1L1, DOT1 or KMT4 is a 1739 amino acid homolog of the yeast DOT1 (disruptor of telomeric silencing-1) protein. Localized to the nucleus and highly expressed in testis, lung and kidney, DOT1L is a histone methyltransferase that transfers methyl groups from S-adenosyl-L-methionine to lysine residues on various substrates, such as nucleosomes or histones. While most histone methyltransferases contain a SET domain through which they confer their enzymatic activity, DOT1L does not contain this characteristic domain and is, therefore, thought to function through a different mechanism. DOT1L can bind with several MLL-fusion partners found in acute leukemia and, through this binding, can promote oncogenesis. Two isoforms of DOT1L are expressed due to alternative splicing events.