P16870

CPE also known as CPH is a member of the M14 family of metallocarboxypeptidases. CPE plays a critical role in prohormone processing, specifically in the removal of C-terminal arginine or lysine residues following initial endoprotease cleavage, which is essential for the maturation of various peptide hormones. This enzymatic activity is particularly important in the processing of proinsulin, ensuring that insulin is produced in its active form, which is vital for glucose metabolism and overall energy homeostasis. Additionally, CPE is necessary for the proper development of photoreceptor synaptic terminals, facilitating normal signal transmission to the inner retina, thereby contributing to visual function.