Q9Y2G2

CARD8 also known as DACAR, NDPP1, TUCAN, CARDINA is a member of the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). CARD8 plays a crucial role in regulating cellular responses mediated by NF-κB activation. Such regulation is vital for maintaining cellular homeostasis and modulating inflammatory responses, making CARD8 an important player in apoptosis and chronic inflammatory disorders. CARD8 interacts with caspase-1, serving as a negative regulator of its activity, which is essential for controlling inflammatory processes. CARD8 has been shown to interact with IKKγ and FHL-2, further highlighting CARD8′s role in complex signaling pathways that influence cell survival and inflammation.