Polyclonal Antibodies - Notch1 Rabbit Polyclonal Antibody

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Notch1 Rabbit Polyclonal Antibody

Catalog #：EAB13564

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB13564-100UL	In Stock	100ul	￡218.90

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IHC-P, IF/ICC
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:50-300　 IF/ICC=1:50-300
MW (kDa)	273
Conjugate	Unconjugate
Specificity	Notch1 Rabbit Polyclonal Antibody detects endogenous levels of Notch1 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Notch receptor 1; hN1; AOS5; TAN1; AOVD1; NOTCH1
Gene Aliases	NOTCH1
UniProt ID	P46531
Entrez Gene ID	4851

Product Description

Notch1 is a member of the NOTCH family of proteins. Notch1 plays a pivotal role in cell fate determination during embryonic and adult development. Upon binding to its ligands, such as Jagged1, Jagged2, and Delta-like proteins, Notch1 undergoes proteolytic cleavage, releasing its intracellular domain, which translocates to the nucleus to regulate gene expression. This signaling pathway is crucial for processes like differentiation, proliferation, and apoptosis, impacting the development of various tissues and organs. Dysregulation of Notch1 has been implicated in several cancers, including T-cell acute lymphoblastic leukemia, highlighting its importance in maintaining cellular homeostasis.

Product Image Gallery
Western blot analysis of extracts on MCF7, 293T cells, using Notch1 Rabbit Polyclonal Antibody (EAB13564) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution. Predicted band size: 273 kDa; Observed band size: 300 kDa

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol