P46531

Notch1 is a member of the NOTCH family of proteins. Notch1 plays a pivotal role in cell fate determination during embryonic and adult development. Upon binding to its ligands, such as Jagged1, Jagged2, and Delta-like proteins, Notch1 undergoes proteolytic cleavage, releasing its intracellular domain, which translocates to the nucleus to regulate gene expression. This signaling pathway is crucial for processes like differentiation, proliferation, and apoptosis, impacting the development of various tissues and organs. Dysregulation of Notch1 has been implicated in several cancers, including T-cell acute lymphoblastic leukemia, highlighting its importance in maintaining cellular homeostasis.