HDAC11(Histone deacetylase 11) also known as HD11 is member of class IV histone deacetylases and plays a pivotal role in the regulation of gene expression by removing acetyl groups from histone proteins, leading to chromatin condensation and transcriptional repression. This enzymatic activity is crucial for various cellular processes, including differentiation, proliferation, and apoptosis, making HDAC11 a key player in maintaining cellular homeostasis and epigenetic regulation. Unlike other HDAC classes, HDAC11 possesses unique structural features that confer specific regulatory functions, including involvement in metabolic pathways and immune response modulation. HDAC11 expression levels are high in vital tissues such as the kidney, heart, brain, skeletal muscle, and testis, where HDAC11 influences tissue-specific gene expression and cellular functions.