Abl2 also known as ARG is a member of the Abelson family of nonreceptor tyrosine protein kinases. Abl2 plays a crucial role in cellular signaling pathways, particularly in regulating cell growth and differentiation. Abl2 contains both SH2 and SH3 domains, which are essential for protein-protein interactions, allowing engagement with various signaling molecules. One significant interaction is with c-Crk, a protein involved in regulating cytoskeletal dynamics and cell migration. Phosphorylation of c-Crk by Arg is vital for modulating these processes, which are important in development and immune responses.