Q96PU5

NEDD4L also konwn as NEDD2 is a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. NEDD4L functions as an E3 ubiquitin-protein ligase, facilitating the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to specific substrate proteins, which are then marked for proteasomal degradation. By ubiquitinating key proteins such as Smad2 and TGFβ RII, NEDD4L inhibits the TGFβ signaling pathway, a critical regulator of cell growth and differentiation. NEDD4L′s ability to modulate these pathways highlights its importance in various cellular processes and potential implications in diseases where TGFβ signaling is dysregulated. NEDD4L is expressed as eight isoforms due to alternative splicing, contributing to functional diversity and regulatory mechanisms within different tissues, particularly in the pancreas, prostate, and kidney where expression is highest.