RanBP3 is a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. RanBP3 plays a crucial role as a scaffold protein that facilitates the assembly of export complexes, particularly by promoting the binding of Crm1 to RCC1 in the presence of Ran GTP. This interaction is vital for the export of proteins and RNA from the nucleus, a process essential for maintaining cellular function and regulating gene expression. Additionally, Ran BP-3′s ability to bind β-catenin highlights involvement in the inhibition of the Wnt signaling pathway, which is important for various developmental processes and cellular functions. The precise regulation of these interactions underscores the significance of Ran BP-3 in cellular transport mechanisms and potential implications in cancer biology and other diseases.