Polyclonal Antibodies - Phospho-SHIP2 (Tyr1135) Rabbit Polyclonal Antibody

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Phospho-SHIP2 (Tyr1135) Rabbit Polyclonal Antibody

Catalog #：EAB13348

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB13348-30UL	In Stock	30ul	€141.70
EAB13348-100UL	In Stock	100ul	€297.70
EAB13348-200UL	In Stock	200ul	€479.70

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	SBT BioChem Srl	Phone：+39 05 7156 8147
	Via Ponte di Bagnolo, 811 Bologna,	E-mail：info@sbtbiochem.it
Italy	Italy	Web：www.sbtbiochem.it

Product Information
Applications	WB, IHC-P, IF/ICC, ELISA
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:50-300 IF/ICC=1:50-300
MW (kDa)	139
Conjugate	Unconjugate
Specificity	Phospho-SHIP2 (Tyr1135) Rabbit Polyclonal Antibody detects endogenous levels of SHIP2 when phosphorylated at Tyr1135.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	INPPL-1; INPPL1; SHIP-2; SHIP2; SHIP2; 51C; INPPL1; OPSMD
Gene Aliases	INPPL1
UniProt ID	O15357
Entrez Gene ID	3636

Product Description

SHIP-2, a homolog of SHIP, is expressed in both hemopoietic and non-hemopoietic cells. In addition to T and B cells, spleen, thymus and lung are shown to coexpress SHIP and SHIP-2. SHIP is also expressed in fibroblasts, heart, skeletal muscle and different brain areas and its expression is enhanced in TSH and EGF-stimulated cells. Like SHIP, SHIP-2 is tyrosine-phosphorylated and associates with Shc after ligation of the B-cell receptor to FcgRII. SHIP-2 causes cell cycle arrest in G1 phase in glioblastoma cells and plays a negative role in regulating the PI 3-kinase-PI 3-kinase B pathway. Both SHIP and SHIP-2 mediate FcgRIIB signaling, including inhibition of proliferation.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol