Sox2 also known as lcc, ysb is a member of the SRY-related HMG-box (SOX) family of transcription factors. Sox2 plays a crucial role in maintaining pluripotency and self-renewal of embryonic stem cells, thereby governing cell fate decisions and orchestrating key developmental processes. Sox2′s nuclear localization is essential for regulating gene expression, influencing pathways fundamental to embryonic development and maintenance of stem cell populations. Dysregulation of Sox2 has been implicated in various developmental disorders and diseases, including certain cancers, underscoring Sox2′s significance in both normal physiology and pathological conditions.