Q05D32

CTDSPL2(CTD small phosphatase-like protein 2) is also known as HSPC058, HSPC129 is a putative RNA-polymerase II carboxy-terminal domain (CTD) phosphatase that belongs to a small subfamily of CTD phosphatases. The CTD of RNA polymerase II contains multiple Y-S-P-T-S-P-S repeats that are phosphorylated during the transcription cycle. In general, CTD phosphatases regulate the reversible CTD phosphorylation state of RNA-polymerase II at several stages of RNA synthesis and during post-transcriptional modification. CTDSPL2 has several structural and functional similarities to other CTD phosphatases, including FCP1, SCP1, DULLARD, and UBLCP1.