TAZ also known as WWTR1 plays a crucial role in cellular signaling and gene expression regulation. TAZ is primarily located in the cytoplasm and nucleus, where TAZ acts as a key mediator in the Hippo signaling pathway, which is essential for controlling cell growth, differentiation, and apoptosis. TAZ may link events at the plasma membrane and cytosketeton to nuclear transcription in a manner that can be regulated by 14-3-3. TAZ shares homology with the WW domain of Yes-associated protein (YAP) and functions as a transcriptional co-activator by binding to the PPXY motif present on transcription factors. 14-3-3 binding requires TAZ phosphorylation on a single Serine 89 residue, resulting in the inhibition of TAZ transcriptional co-activation through 14-3-3-mediated nuclear export.