Q16620

TrkB also known as NTRK2 is a member of the tropomyosin receptor kinase family and serves as a crucial tyrosine kinase receptor for neurotrophic factors including brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3). These interactions are fundamental for the development, maintenance, and function of the central and peripheral nervous systems, playing a vital role in neuronal survival, differentiation, and synaptic plasticity. The activation of TrkB by ligands initiates downstream signaling pathways that regulate essential cellular processes, making TrkB a key player in understanding neurological diseases and developing therapeutic interventions.