P78369

Claudin-10 also known as CLDN10 is a member of the claudin family. Claudin-10 is a critical component of tight junctions, which are essential for maintaining the integrity of epithelial and endothelial barriers. These tight junctions regulate paracellular transport, ensuring that substances pass through the spaces between cells in a controlled manner. Claudin-10 consists of four transmembrane domains and two extracellular loops, which facilitate its role in cell adhesion and the formation of tight junction strands. Notably, Claudin-10 is involved in the selective permeability of tight junctions, allowing for the passage of certain ions and small molecules while blocking others, which is vital for maintaining homeostasis in various tissues.