P16234

PDGF Receptor α also known as PDGFR alpha, PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. plays a crucial role in cellular processes such as proliferation, survival, and migration, making PDGFR-α essential for normal development and tissue repair. PDGFR-α is primarily located on the cell surface, where PDGFR-α interacts with PDGF-AA and PDGF-AB ligands to initiate signaling cascades that influence cell behavior. PDGFR-α′s ability to form homodimers and heterodimers upon ligand binding is vital for function, as this formation determines the specificity and strength of the signaling response. Dysregulation of PDGFR-α signaling has been implicated in various pathologies, including cancer and fibrotic diseases, highlighting PDGFR-α′s importance in both health and disease.