Q07820

Mcl-1 also known as Myeloid cell leukemia-1, Mcl1, Gm52627 is a critical anti-apoptotic protein within the B-cell lymphoma 2 (Bcl-2) family that plays a vital role in regulating cell survival by inhibiting apoptosis through interactions with pro-apoptotic proteins like Bak and Bax, thereby preventing mitochondrial outer membrane permeabilization and cytochrome c release, essential steps in the intrinsic apoptotic pathway. Mcl-1 functions to ensure normal development, tissue homeostasis, and immune system function, particularly in the maintenance of B and T lymphocyte populations. Dysregulation or overexpression of Mcl-1 can lead to the survival of abnormal cells and has been implicated in the development of various cancers, including leukemia, lymphoma, and solid tumors, making Mcl-1 an important target for cancer research and therapeutic intervention.