Wnt2b also known as WNT13, XWNT2 is a member of the wingless-type MMTV integration site (WNT) family. Wnt2b plays a crucial role in cell signaling and development. Wnt2b belongs to the Wnt family of proto-oncogenes, which are essential for various biological processes, including cell fate determination and embryogenesis. Wnt2b functions as a ligand for transmembrane receptor proteins, initiating signaling pathways that influence tissue differentiation and development. Wnt2b expression appears in various cancer cell lines, indicating potential involvement in tumorigenesis and making Wnt2b a significant target for cancer research. Wnt2b presence in both adult and fetal tissues, through two isoforms, highlights Wnt2b importance in developmental biology and cancer progression studies.