Recombinant Antibodies - Phospho-TrkA (Tyr490)/TrkB (Tyr516) Rabbit Monoclonal Antibody

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Phospho-TrkA (Tyr490)/TrkB (Tyr516) Rabbit Monoclonal Antibody

Catalog #：EAB22117

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB22117-100UL	In Stock	100ul	€336.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	Betaclonal	Phone：+34 (0)91 471 6763
	29/1 Lomonosovsky Pr,	E-mail：tech@betaclonal.com
Spain	Madrid, Spain	Web：www.betaclonal.com

Product Information
Applications	WB
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000
MW (kDa)	87, 92
Conjugate	Unconjugate
Specificity	Phospho-TrkA (tyr490)/TrkB (Tyr516) Rabbit Monoclonal Antibody detects endogenous levels of TrkA and TrkB protein only when phosphorylated at Tyr490 and Tyr516.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	GP145-TrkB; GP145-TrkB/GP95-TrkB; MTC; NTRK1; NTRK2; p140-TrkA; RATTRKB1; Tkr; Tkrb; TRK; Trk-A; trk-B; TRK1; TRKA; TRKB; TRKB1;
Gene Aliases	NTRK1/NTRK2
UniProt ID	P04629, Q16620
Entrez Gene ID	4914, 4915

Product Description

The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by NTRK2, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, encodes a protein designated Trk C gp145 that is preferentially expressed in brain tissue, is equally related to Trk A and Trk B and is a functional receptor for NT-3.

Product Image Gallery
Western blot analysis of extracts on different cells, using Phospho-TrkA (tyr490)/TrkB (Tyr516) Rabbit Monoclonal Antibody (EAB22117) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution. Lane1: K562 Lane2: NIH/3T3 Predicted band size: 87,92 kDa; Observed band size: 140 kDa

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol