PELP1 also known as MNAR, P160 is a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors.  PELP1 plays a critical role in modulating estrogen receptor activity, which is vital for understanding cancer progression, particularly in endometrial cancers. PELP1 is primarily located in the cytoplasm of cells, where PELP1 interacts with estrogen receptors and other nuclear hormone receptors, influencing their transcriptional activity. This subcellular localization allows PELP1 to participate in both genomic and non-genomic signaling pathways, thereby affecting cellular proliferation and differentiation. PELP1′s expression is often deregulated in endometrial tumors, highlighting PELP1′s potential as a biomarker for cancer diagnosis and prognosis.