Recombinant Antibodies - PEN2 Rabbit Monoclonal Antibody

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PEN2 Rabbit Monoclonal Antibody

Catalog #：EAB22113

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB22113-100UL	In Stock	100ul	€297.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	SBT BioChem Srl	Phone：+39 05 7156 8147
	Via Ponte di Bagnolo, 811 Bologna,	E-mail：info@sbtbiochem.it
Italy	Italy	Web：www.sbtbiochem.it

Product Information
Applications	WB, IHC-P, IF/ICC, FC
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:50-200　 IF/ICC=1:50-200 FC=1:10-100
MW (kDa)	12
Conjugate	Unconjugate
Specificity	PEN2 Rabbit Monoclonal Antibody detects endogenous levels of PEN2 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Presenilin Enhancer 2; PEN2; PEN-2; MDS033; ACNINV2; MSTP064; PSENEN
Gene Aliases	PSENEN
UniProt ID	Q9NZ42
Entrez Gene ID	55851

Product Description

PEN2 also known as PSENEN is a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. PEN2 plays a crucial role in the assembly and function of the gamma-secretase complex, which is essential for the proteolytic processing of type I membrane proteins, including the amyloid-beta precursor protein. This processing is particularly significant as PEN2 is linked to the pathogenesis of Alzheimer′s disease, where the accumulation of amyloid-beta peptides is a hallmark. The gamma-secretase complex, composed of presenilin, nicastrin, aph-1, and PEN2, assembles in the Golgi/trans-Golgi network compartments, leading to the autocleavage of presenilin into two subunits that form the active site of gamma-secretase.

Product Image Gallery
Western blot analysis of extracts on Hela, SH-SY5Y, A549, 293T cells, using PEN2 Rabbit Monoclonal Antibody (EAB22113) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol