P26599

PTBP1 also known as hnRNP I is located on chromosome 19p13.3, and interaction with other hnRNP proteins, like hnRNP L, underscores importance in the spliceosome′s composition, which is vital for mRNA processing. hnRNP I plays a crucial role in regulating alternative splicing of pre-mRNAs, which is essential for generating protein diversity and regulating gene expression. hnRNP I is primarily localized in the nucleoplasm, where binding to the 3′ end of introns influences splicing mechanisms in normal cellular processes and translation of certain viruses, such as hepatitis C virus (HCV). hnRNP I′s ability to shuttle between the nucleus and cytoplasm further highlights significance in mRNA transport and translation, making this protein a key player in cellular function and viral pathogenesis.