P20393

Rev-erbα also known as NR1D1 is a transcription factor. Rev-erbα plays a crucial role in regulating circadian rhythms and metabolic processes by acting as a transcriptional repressor. Rev-erbα is primarily located in the nucleus, where Rev-erbα binds to specific DNA sequences to modulate gene expression. Nuclear localization enables Rev-erbα to interact with other nuclear proteins and transcription factors, thereby influencing the expression of genes involved in circadian rhythm regulation and lipid metabolism. Rev-erbα interacts with co-activator NCOA5, which enhances transcriptional activity, highlighting Rev-erbα′s importance in the intricate network of gene regulation.