P61764

Unc18-1 also known as MUNC18, STXBP1 is a syntaxin-binding protein. Unc18-1 protein plays a crucial role in regulating exocytosis by acting as a chaperone that prevents premature interactions between syntaxin and soluble NSF attachment protein receptors, which are essential for vesicle fusion and neurotransmitter release. This regulation is vital for maintaining proper cellular communication and function, particularly in neurons and endocrine cells. Additionally, Unc18-1 undergoes post-translational modifications, including phosphorylation at specific sites such as Ser 313 and Thr 574, which modulate interactions with Syntaxin 1A and influence exocytotic processes. Unc18-1 mRNA expression in various cell types, including RBL-2H3 mast cells and mouse bone marrow-derived mast cells, underscores its importance in immune responses and cellular signaling pathways.