Polyclonal Antibodies - MAD2L1 Rabbit Polyclonal Antibody

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MAD2L1 Rabbit Polyclonal Antibody

Catalog #：EAB14782

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB14782-30UL	In Stock	30ul	￡97.90
EAB14782-100UL	In Stock	100ul	￡218.90
EAB14782-200UL	In Stock	200ul	￡372.90

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email us at info@ebiocell.com

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IP, ELISA
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000　 IP=1:100-500
MW (kDa)	24
Conjugate	Unconjugate
Specificity	MAD2L1 Rabbit Polyclonal Antibody detects endogenous levels of MAD2L1 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	HSMAD2; MAD-2; MAD2like1; MAD2 mitotic arrest deficient like 1; MAD2B; MAD2L1; Mitotic arrest deficient 2; REV7; MD2L1; MAD2
Gene Aliases	MAD2L1
UniProt ID	Q13257
Entrez Gene ID	4085

Product Description

MAD2L1 (also designated MAD2) is a component of the mitotic spindle checkpoint. Cells with mutated MAD2 do not undergo mitotic arrest in response to incorrect spindle fiber assembly, which results in missegregation and eventual cell death. MAD2L1 is localized to unattached kinetochores during prometaphase and disassociates upon spindle fiber attachment, indicating that MAD2L1 regulates kinetochore binding to the spindle fibers. Human MAD2L1 has also been shown to associate with insulin receptor (IR), but not IGFIR, implicating MAD2L1 as a mediator for IR-specific signaling.

Product Image Gallery
Western blot analysis of extracts on different cells, using MAD2L1 Rabbit Polyclonal Antibody (EAB14782) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution. Lane1: K562 Lane2: A549 Lane3: HuvEc

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol