O14920

IKKβ also known as IKBKB is a member of the serine/threonine protein kinase family.  IKKβ plays a crucial role in the activation of the transcription factor NFκB, which is essential for regulating immune responses, inflammation, and cell survival. Located primarily in the cytoplasm, IKKβ interacts with IκB proteins, facilitating their phosphorylation and subsequent degradation, which allows NFκB to translocate to the nucleus and initiate the transcription of target genes. The proper functioning of IKKβ is vital, as dysregulation can lead to various diseases, including cancer and autoimmune disorders. Additionally, IKKβ undergoes post-translational modifications, such as phosphorylation, which can influence activity and interactions with other proteins, further underscoring importance in cellular signaling pathways.