INPP4b plays a crucial role in cellular signaling by selectively dephosphorylating phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate, generating second messengers that mediate various physiological responses to extracellular signals. INPP4b is predominantly located in the cytoplasm and regulates intracellular calcium levels, which is vital for numerous cellular processes, including muscle contraction, neurotransmitter release, and cell proliferation. INPP4b appears in various tissues, such as human platelets, rat brain, heart, skeletal muscle, and spleen, underscoring its importance in maintaining cellular homeostasis and responding to external stimuli.