IGKC also known as Ig κ chain plays a crucial role in immune response, as one of two types of light chains forming part of immunoglobulin structure, essential for specificity and functionality of antibodies. Immunoglobulins, composed of two identical heavy chains and two identical light chains, are vital for recognizing and binding to antigens, facilitating their removal from the body. Kappa light chain presence influences overall stability and affinity of antibodies for target antigens. In humans, kappa light chain genes are located on chromosome 2, and their rearrangement during B cell development creates diverse antibody repertoires capable of responding to various pathogens. Unique genetic combinations of heavy and light chains enable production of antibodies with specific binding sites, fundamental for effective immune responses.