Glypican-1 also known as GPC1 is a member of the glycosylphosphatidylinositol-anchored cell surface heparan sulfate proteoglycans, playing a significant role in cell adhesion, migration, and growth factor activity modulation. Glypican-1 interacts with fibroblast growth factors (FGFs), such as FGF-1, FGF-2, and FGF-7, which are essential for various cellular processes, including proliferation and differentiation. Glypican-1′s heparan sulfate chains facilitate binding to vascular endothelial growth factor 165 (VEGF165), acting as an extracellular chaperone that restores receptor binding ability after oxidative stress. This interaction supports hematopoietic stem and progenitor cell maintenance through Glypican-1 expression on marrow stromal cells. Glypican-1 shows elevated expression in human pancreatic cancer cells compared to normal pancreatic cells, suggesting involvement in tumor microenvironment and response to mitogenic stimuli like FGF-2.