DGK-α also known as DGKA belongs to the eukaryotic diacylglycerol kinase family. DGK-α plays a crucial role in cellular signaling by phosphorylating diacylglycerol (DAG) to generate phosphatidic acid, which are both important lipid second messengers involved in various signaling pathways. This enzymatic activity is vital for regulating cell activation and the secretion of exosomes that can influence cell death, thereby impacting processes such as immune response and cancer progression. Additionally, DGK-α is known to interact with other proteins involved in signaling pathways, further emphasizing its importance in cellular communication and function. The expression of DGK-α is particularly notable in immune cells, where DGK-α modulates responses to external stimuli, making DGK-α a significant target for research in immunology and therapeutic interventions.