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CBX4 Rabbit Polyclonal Antibody
Catalog #£ºEAB11741
  SKU-Pack Size Availability Size Price
EAB11741-30UL In Stock 30ul €115.70
EAB11741-100UL In Stock 100ul €258.70
EAB11741-200UL In Stock 200ul €440.70
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Product Information
Applications WB
Species Reactivity Human, Mouse
Host / Isotype Rabbit IgG
Clonality Polyclonal
Applications Dilutions WB=1:500-2000
MW (kDa) 61
Conjugate Unconjugate
Specificity CBX4 Rabbit Polyclonal Antibody detects endogenous levels of CBX4 protein.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20¡ãC least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4¡ãC for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) PC2; NBP16
Gene Aliases CBX4
UniProt ID

O00257

Entrez Gene ID

8535

Product Description

CBX4 suitable for the detection of the CBX4 protein. Polycomb group (PcG) proteins form multiprotein complexes and play a role in gene silencing (1,2) and Hox gene regulation by altering chromatin structure during transcription. The PcG protein CBX4, also known as, PC2 or NBP16, maps to human chromosome 17q25.3. CBX4 and CBX8 are PcG proteins that show structural similarity to M33 and, like M33, bind the PcG protein RING1 through a conserved c-box motif located in the C-terminus of RING1 (1,2,5). CBX4 is a repressor of proto-oncogene activity, thus interference with CBX4 function can lead to depression of proto-oncogene transcription and subsequently to cellular transformation. CBX4 is able to act as a long range transcriptional silencer (1,7). CBX4 is expressed in the human osteosarcoma cell line U-20S. CBX4 is part of a large multiprotein complex that also contains other PcG proteins including Bmi-1 (1,7).

Product Image Gallery
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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