FCGR2A also known as Fc gamma RIIa, CD32a is a member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. CD32 plays a crucial role in the immune response by mediating the clearance of immune complexes through macrophages. This function is vital for maintaining homeostasis and preventing autoimmune reactions, as the binding of IgG to CD32 delivers inhibitory signals to B cells, thereby regulating antibody production. CD32 exists in several isoforms generated by alternative splicing of three distinct genes (A, B, and C), which are designated FcgRIIA, FcgRIIB1, FcgRIIB3, and FcgRIIC. These isoforms are expressed on various immune cells, including monocytes, placental trophoblasts, endothelial cells, and B lymphocytes, with specific isoforms found on neutrophils, highlighting CD32′s diverse roles in immune regulation and response.